Kratom Drug Interactions – Never Combine them

kratom drugs

Historical records suggest Kratom, (Mitragyna speciosa) is a tree indigenous to Southeast Asia, widely celebrated for its pain-relief and energy-boosting potentials.

In old Thailand and Malaysia, farmers chewed the fresh leaves to increase stamina while working their fields. Kratom was also used to treat wounds and alleviate associated pains.

Kratom leaves are rich in compounds that deliver psychoactive effects. Interestingly, the plant contains over 40 alkaloids and many flavonoids found across the different parts of the tree.

These compounds deliver a range of effects – from therapeutic to recreational – which accounts for the surge in demand for kratom. 

What is Kratom Used For?

In more recent times, kratom has been applied for practically the same purposes as in the past. Except that, currently, Kratom users have more dosage options.

For example, presently, Kratom herb is used for similar therapeutic purposes as opioids and other related stimulants – primarily for pain relief and energy boost.

Recreationally, Kratom is prized for its psychoactive effect (otherwise called ‘high’) particularly when consumed in large amounts.

With decent doses, Kratom may deliver milder and, perhaps, more beneficial effects– increased energy, sociability, and alertness – as against the couchlock effect from large amounts.

Because it binds to similar receptors as some opioids, Kratom may be a more natural non-addictive alternative to the conventional chemical packed painkillers and energy boosters.

In the US, Kratom is basically used to:

  • Self-treat acute and chronic pain
  • Manage opioid addiction
  • Manage emotional or mental health conditions

How is Kratom Used?

Originally, the locals plucked fresh kratom leaves, removed the veins, and chewed. Over time, commercial producers found better ways to preserve the herb as it gained wide acceptance and demands across distant regions and countries.

Kratom leaves are dried and blended into powder to increase its shelf life and for easier and more flexible applications. 

Here are the most common ways people use kratom:

  • Infused into beverages – Many users prefer to stir powdered kratom into drinks such as orange juice or even tea. It’s acclaimed that the components in citrus activate the drug quickly and bring about a more rapid effect. This way, the beverage’s taste and flavor overrides kratom’s earthy taste. 
  • Toss n wash – Alternatively, some users take a spoonful of Kratom powder down their throat and quickly flush down with a cup of water or juice. This common practice is referred to as ‘Toss and Wash’.
  • Capsules – as with conventional pharmaceuticals, Kratom powder could be filled into capsules and swallowed with water or your favorite beverage. This option allows users to gauge their consumption level and eliminate mess.
  • Inhalation: While not the healthiest dosage form, like weed, recreational users smoke  dried kratom leaves. 

There is  no one best way to consume kratom. It’s all based on your purpose of using the herb and other personal preferences. For instance, if you’re an on-the-go kratom user, preferring capsules is a no brainer. 

Kratom Drug Interaction

Kratom’s use usually comes with but minimal side effects – weight loss, muscle pain, and constipation.

Kratom could also affect the mind and nervous system, causing hallucinations, seizures, and related undesirables. However, many of these situations are a result of excessive dosage or prolonged consumption.

There’s one noteworthy danger to watch out for when using Kratom – Kratom drug interaction.

Many patients believe they’ll get a better effect when they mix their pharmaceutical prescriptions with other non-conventional supplements. But this practice has caused more harm than good.

While a few reviews say Kratom may be fatal, the fact is, in most of these cases, other drugs, such as cocaine, were the actual cause – not kratom.

The Foods and Drugs Administration also reported many Kratom-associated casualties in 2017 to be as a result of adulterated Kratom or the consumption of Kratom with other substances like opioids.

Such findings suggest, strongly, the probable dangers of combining Kratom with other drugs.

Why So?

As with any drug, when ingested, kratom goes through a channel. I.e, from absorption to distribution, metabolism, and, finally, excretion.

At each point, the body’s mechanisms monitor these effects and try to prevent adverse reactions to these drugs.

A major issue when using kratom and other drugs is the possible interaction of chemicals in the substances which may inhibit metabolizing enzymes, particularly the CYPs.

These enzymes are responsible for metabolizing more than 50% of conventional drugs including opioids and antidepressants. The major constituents of Kratom – Mitragynine and 7-hydroxy mitragynine – may be strong inhibitors of these enzymes, thus delaying their metabolism level, significantly.

What then?

Kratom is a highly potent substance. No use combining with other drugs to get a full effect.

In the event you think a combo will be better, please speak to us or consult your doctor before you use other medications.

It is also advisable that you purchase your Kratom powder only from trusted online vendors as some vendors now lace their Kratom with other compounds less potent and more harmful materials. Besides their ineffectiveness, such products can leave you worse than ever. 

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